Description
Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In nonneoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, forming complexes of 16nm crystalline particles. UPIII isspecific for tumors of urothelial origin and, when used in combination with other markers, can aid in the diagnosis of primary and metastatic tumors.
Additional information
| Catalog No. | Mob594 Concentrated, PDM594 Prediluted |
|---|---|
| Clone | AU1 |
| Isotype | IgG1 |
| Immunogen | Raised in mouse using AUM preparation from bovine urinary bladder as the immunogen. |
| Species | Mouse |
| Cellular Localization | Cytoplasmic and Membranous |
| Positive Control Tissue | Bladder Carcinoma |
| Pretreatment | EDTA Buffer pH8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | Tissue Culture Supernatant |
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